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Anesthesia Induction with the Target-controlled Infusion of Propofol in High-risk Patients

NCT06535230 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2025-02-03

No results posted yet for this study

Summary

The purpose of this study is to compare the risk of hypotension following induction of anesthesia in high-risk patients (American Society of Anesthesiologists risk scores III and IV) using target-controlled infusion (TCI) of propofol versus standard manual induction of anesthesia. Our previously published study compared TCI and manual induction of anesthesia in a general patient population and found that hypotension developed less with TCI induction. This study is a continuation of the other study and will be conducted in high-risk patients.

Conditions

  • Anesthesia
  • Hemodynamic Instability

Interventions

DRUG

Manual anesthesia induction

In manual anesthesia induction, anesthetic agents are administered at a fixed dose and rate adjusted according to the patient's weight

DRUG

Anesthesia induction with Target controlled infusions (TCI)

Target controlled infusion (TCI) system aims to reach the theoretically targeted blood or brain concentration of anesthetic agents based on the patient's age, weight, and height, with computer-assisted algorithms.

DEVICE

Hemodynamic monitoring with pressure recording analytical method (PRAM)

The pulse contour device MostCare (Vytech, Vygon, Padova, Italy) provides functional hemodynamic monitoring using the pressure recording analytical method.

Sponsors & Collaborators

  • Acibadem University

    lead OTHER

Principal Investigators

  • Fevzi Toraman, M.D. · Acibadem Mehmet Ali Aydinlar University School of Medicine, Department of Anesthesiology

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-30
Primary Completion
2025-05-30
Completion
2025-06-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06535230 on ClinicalTrials.gov