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Observation of Propofol Titration at Different Speeds

NCT04595591 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 276

Last updated 2022-11-08

No results posted yet for this study

Summary

Propofol is one of the most widely used anesthetics for its fast onset and quick elimination. The conventional speed of its induction dose often causes severe hemodynamics fluctuations with hypotension and arrhythmia. The recommended dosage on the drug insert comes from group pharmacokinetic studies which does not apply to the specific situation of every patient, so the investigators emphasize individualized medication. The investigators have observed the titration of propofol in general anesthesia induction, and found that the dosage was less and the hemodynamics was becoming more stable. At the same time, the investigators found that the hemodynamics still has obvious fluctuations in the titration of the administration rate recommended in the instructions. The investigators intend to further compare the effects of propofol titration administration at different rates for hemodynamics and stress during the induction period of general anesthesia, and find a safer and more appropriate rate of administration.

Conditions

  • Anesthesia, General
  • Hemodynamics

Interventions

DRUG

2mg/kg/min

titration dosing speeds of propofol at 2mg/kg/min

DRUG

1mg/kg/min

titration dosing speeds of propofol at 1mg/kg/min

DRUG

0.5mg/kg/min

titration dosing speeds of propofol at 0.5mg/kg/min

Sponsors & Collaborators

  • SanQing Jin

    lead OTHER

Principal Investigators

  • SanQing Jin, MD · The Sixth Affiliated Hospital, Sun Yat-sen University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-23
Primary Completion
2021-03-25
Completion
2021-04-25

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04595591 on ClinicalTrials.gov