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Autonomic Modulation After Propofol Target Controlled Infusion and Bolus Administration

NCT03954262 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2020-02-12

No results posted yet for this study

Summary

Some studies have compared the clinical profile during propofol induction anesthesia with Target-controlled infusion (TCI) and manually bolus showed similar control of anesthesia, such as depth of anaesthesia and hemodynamic stability, but did not use an objective measure of instantaneous autonomic activity during the brief time of induction anesthesia. In this study, TCI and manually bolus of propofol injection techniques during induction were studied with wavelet-based spectral analysis and the amplitudes of the pulse plethysmographic. The investigators hypothesized that during propofol induction anesthesia, the instantaneous ANS activities was more stable with TCI than traditional manually bolus

Conditions

  • Anesthesia
  • Autonomic Imbalance

Interventions

BEHAVIORAL

observation of propofol ANS response

received an induction bolus or TCI infusion of propofol

Sponsors & Collaborators

  • National Central University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-25
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03954262 on ClinicalTrials.gov