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The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

NCT01638624 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2016-06-13

No results posted yet for this study

Summary

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.

Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Conditions

  • Total Knee Arthroplasty
  • Tourniquet-Induced Ischemia-Reperfusion Injury

Interventions

DRUG

Propofol

Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol.

DRUG

Placebo

Sponsors & Collaborators

  • Diskapi Teaching and Research Hospital

    lead OTHER

Principal Investigators

  • Derya Özkan, MD · Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic

  • Taylan Akkaya, MD · Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic

  • Ali Yalcindag, MD · Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic

  • Tuba Hanci, MD · Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic

  • Haluk Gümüs, MD · Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic

  • Namik Delibas, MD · Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic

  • Emel Gönen, Consultant · Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Orthopedics Clinic

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-06-30
Primary Completion
2012-10-31
Completion
2012-11-30

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01638624 on ClinicalTrials.gov