MedTrace Logo

Population Pharmacodynamic Modeling of the Sedative and Side Effects of Propofol

NCT02173340 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2015-07-29

No results posted yet for this study

Summary

Sedation during spinal anesthesia is very useful for patients' comfort. However, intermittent bolus of sedative frequently results in inappropriate sedation which comes with various side effects such as patients' discomfort and apnea. Therefore, it would be reasonable to use target-controlled infusion(TCI) to provide proper sedation without serious side effects.

In this study, the investigators try to find the appropriate propofol target concentration with TCI device and build a pharmacodynamic non-linear mixed effect model between propofol target concentration and side effects.

Conditions

  • Surgery Related to Lower Extremity Under Spinal Anesthesia

Sponsors & Collaborators

  • Yonsei University

    lead OTHER

Principal Investigators

  • Dong Woo Han, MD, PhD · Yonsei University Gangnam Severance Hospital

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-06-30
Primary Completion
2014-09-30
Completion
2014-09-30

Countries

  • South Korea

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02173340 on ClinicalTrials.gov