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Diabetes Risk in London and Its Association with Vitamin D by Ethnic Group (DELVE)

NCT06241976 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 111

Last updated 2025-03-12

No results posted yet for this study

Summary

The goal of this study is to investigate the relationship between vitamin D status and a diabetes risk factor, postprandial glycaemic response in White, South Asian and Black African Caribbean populations in London.

The main question\[s\] it aims to answer are:

* Are there differences in postprandial glycaemic response to a sugar water drink or orange juice between White, South Asian and Black African Caribbean people in London?
* Is there a relationship plasma 25(OH)D and the postprandial glycaemic response to a sugar water drink or orange juice consumption?
* What are the knowledge and perceptions of vitamin D intake between White, South Asian and Black African Caribbean people in London?
* Is there a difference in dietary vitamin D intake between the three ethnic groups?

Participants will make two visits to the lab, approximately 2.5 hours each. The order of the two drinks will be randomized via Excel Random function. For each visit, the blood sugar levels will be measured at fasting (0) and every 30 minutes up to 2 hours postprandially (5 times total) using a finger prick. At baseline only (visit 1), participants will fill out a knowledge and perception survey, provide a 4-day estimated food diary, provide a 7 ml blood sample via phlebotomy, and have their height, weight and body fat percentage measured.

Conditions

  • Hyperglycemia, Postprandial
  • Vitamin D Status

Interventions

OTHER

Glucose drink

75g glucose in 300 ml water (281 kcal) used for oral glucose tolerance test (OGTT)

OTHER

Pure orange juice

300ml pure orange juice (OJ, Tesco 100% Pure Squeezed Orange Juice Smooth containing 129 kcal, 30 g sugar, 0.3 g fibre, 1.8 g protein and 90 mg vitamin C) from Tesco supermarket

Sponsors & Collaborators

  • Barts & The London NHS Trust

    collaborator OTHER

  • City, University of London

    lead OTHER

Principal Investigators

  • Honglin Dong · City, University of London

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-01
Primary Completion
2025-02-28
Completion
2025-02-28

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06241976 on ClinicalTrials.gov