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Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults

NCT05891977 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 47

Last updated 2025-06-25

No results posted yet for this study

Summary

Tomatoes and tomato-based products could play an important role in modulating microbiota-gut-brain axis (MGBA) interactions due to their high content of fiber and phytochemicals. Phytochemical metabolites derived from the consumption of tomato-based products can act directly as neurotransmitters in the central nervous system, crossing the blood-brain barrier, or indirectly by modulating the MGBA. These metabolites can thus alter gut bacterial composition and brain biochemistry. Therefore, researchers propose a new interventional study to assess the impact of daily tomato consumption in the organism, and to evaluate the effect on the MGBA. The final aim of this study is to spread a message of the health benefits of tomato consumption for the general population.

Conditions

  • Microbiota
  • Cognitive Function
  • Healthy Lifestyle

Interventions

OTHER

Intervention A - Tomato paste

Participants will consume a daily amount of 0.5 g of tomato paste / kg of body weight following the regular diet plus consumption of low to moderate tomato or tomato-based products and lycopene containing foods

OTHER

Intervention B - Control

Participants will consume the regular diet plus consumption of low to moderate tomato or tomato-based products and lycopene containing foods

Sponsors & Collaborators

  • University of Barcelona

    lead OTHER

Principal Investigators

  • Rosa M Lamuela Raventós, PhD · University of Barcelona

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-25
Primary Completion
2024-12-04
Completion
2024-12-04

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05891977 on ClinicalTrials.gov