Effects of Tomato Consumption on Steatosis, Intestinal Function and Glucose and Lipid Metabolism in Subjects With NAFLD

Summary

The study in question is an interventional study with nutritional intervention. the aim of the study is to evaluate whether a diet enriched with tomatoes can have favorable effects on:

* specific aspects associated with NAFLD, such as the degree of hepatic steatosis and fibrosis;
* circulating levels of molecules correlated with the degree of generalized and hepatic inflammation and the blood concentrations of metabolic and cardiovascular risk factors associated with abdominal obesity;
* intestinal barrier;
* body composition;
* intestinal microbiota;
* symptoms of IBS (irritable bowel syndrome) in patients with NAFLD.

Conditions

• NAFLD
• IBS

Interventions

DIETARY_SUPPLEMENT

Experimental: Case Group - Tomato-free diet

Nutritional intervention without tomatoes and sauce

DIETARY_SUPPLEMENT

Experimental: Case group - Diet enriched with tomatoes

Nutritional intervention enriched with tomatoes and souce

Sponsors & Collaborators

• Dr. Di Stasi Vincenza

  collaborator UNKNOWN

• Dr. Donvito Rosanna

  collaborator UNKNOWN

• Dr. Cozzolongo Raffaele

  collaborator UNKNOWN

• Dr. Giannuzzi Vito

  collaborator UNKNOWN

• Dr. Zappimbulso Marianna

  collaborator UNKNOWN

• Dr. Shahini Endrit

  collaborator UNKNOWN

• Dr. Notarnicola Maria

  collaborator UNKNOWN

• Dr. Russo Francesco

  collaborator UNKNOWN

• Dr. Riezzo Giuseppe

  collaborator UNKNOWN

• Dr. Donghia Rossella

  collaborator UNKNOWN

• Dr. Cesternino Anna Maria

  collaborator UNKNOWN

• Dr. Cici Rosalisa

  collaborator UNKNOWN

• Dr. Cerabino Nicole

  collaborator UNKNOWN

• Dr. Martina Di Chito

  collaborator UNKNOWN

• Dr. Pesole Pasqua Letizia

  collaborator UNKNOWN

• Dr. Coletta Sergio

  collaborator UNKNOWN

• Dr. Stabile Dolores

  collaborator UNKNOWN

• Dr. Ancona Anna

  collaborator UNKNOWN

• Dr. D'Attoma Benedetta

  collaborator UNKNOWN

• Dr. Ignazzi Antonia

  collaborator UNKNOWN

• Dr. De Nunzio Valentina

  collaborator UNKNOWN

• Dr. Tatoli Rossella

  collaborator UNKNOWN

• Dr. Pinto Giuliano

  collaborator UNKNOWN

• Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-05-14

Primary Completion

2025-05-20

Completion

2026-01-20

Countries

• Italy

Study Locations