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Effect of Mediterranean Diet and Probiotics in Adults With Mild Cognitive Impairment

NCT05029765 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2021-09-01

No results posted yet for this study

Summary

Manipulation of the gut microbiota through dietary modification affects brain function, with improvement in patients with cognitive disorders. Combined effect of nutritional intervention with Mediterranean diet and probiotics with potentially healthy growth of germ, affect the evolution of mild cognitive impairment, by the modulation of components related with the axis microbiota-gut-brain: neuropeptides, short-chain fatty acids, markers for oxidative stress and inflammation.

Conditions

Interventions

DIETARY_SUPPLEMENT

Mediterranean diet

Mediterranean diet: 22% Monounsaturated fat, 6% Polyunsaturated fat, 7% Saturated fat, 15% Protein, 50% Carbohydrates

DIETARY_SUPPLEMENT

Healthy diet (WHO recommendations)

Recommendations according to WHO

DIETARY_SUPPLEMENT

Placebo

Placebo

DIETARY_SUPPLEMENT

Biopolis-MIX42

Biopolis-MIX42: a capsule containing 10\^9 colony forming units of Lactobacillus rhamnosus and Bifidobacterium longum.

Sponsors & Collaborators

  • Pablo Pérez Martínez

    lead OTHER

Principal Investigators

  • Pablo Perez-Martinez, PhD, MD · IMIBIC/ Reina Sofia University Hospital / University of Cordoba

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-26
Primary Completion
2020-03-05
Completion
2020-03-05

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05029765 on ClinicalTrials.gov