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Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment

NCT05583643 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2022-10-19

No results posted yet for this study

Summary

Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss. Various topical anti-inflammatory drugs were used to treat inflammation in periodontitis. Introducing atorvastatin as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of targeting inflammation within the periodontal pockets.

Conditions

  • Periodontitis

Interventions

DRUG

Atorvastatin Calcium

Atorvastatin loaded into nano particles in-situ gel adjunctive to scaling and debridement

DRUG

Atorvastatin Calcium

Atorvastatin loaded into in-situ gel adjunctive to scaling and debridement

OTHER

Scaling and debridement only

Scaling and debridement only

Sponsors & Collaborators

  • Misr University for Science and Technology

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-12-07
Primary Completion
2022-04-15
Completion
2022-06-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05583643 on ClinicalTrials.gov