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The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

NCT06669026 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2024-11-01

No results posted yet for this study

Summary

The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.

Conditions

  • Periodontal Pocket

Interventions

DIETARY_SUPPLEMENT

vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel

Scaling and root debridement then inject gel in the pocket

DIETARY_SUPPLEMENT

vitamin D3 gel (regular non-nanoparticle form)

Scaling and root debridement then inject gel in the pocket

OTHER

Poly lactic-co-glycolic acid nanoparticles placebo gel

Scaling and root debridement then inject gel in the pocket

PROCEDURE

only mechanical debridement

Scaling and root debridement

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
25 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2024-03-15
Completion
2024-09-20

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06669026 on ClinicalTrials.gov