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Nitazoxanide as a New Local Adjunctive to Nonsurgical Treatment of Moderate Periodontitis

NCT04768530 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-02-24

No results posted yet for this study

Summary

The aim of the study was to assess the effect of nitazoxanide delivered subgingivally as thermosensitive hydrogel on the clinical and biochemical outcomes of SRP in patients with moderate periodontitis.

Conditions

  • Periodontitis

Interventions

PROCEDURE

Scaling and Root Planing

Supra- and sub-gingival calculus and debris were removed

DRUG

Nitazoxanide hydrogel

Scaling and root planing was performed in combination with the subgingivally delivered thermosensitive Nitazoxanide hydrogel as adjunct antimicrobial therapy.

Sponsors & Collaborators

  • Maha Talaab

    lead OTHER

Principal Investigators

  • Maha R. Taalab, PhD · Faculty of Dentistry, Alexandria University, Egypt

  • Sylvia Farid, BDS · Faculty of Dentistry, Alexandria University, Egypt

  • Shaimaa Maklad, PhD · Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt

  • Labiba El-Khordagui, PhD · Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt

  • Maha El Tantawi, PhD · Faculty of Dentistry, Alexandria University, Egypt

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-20
Primary Completion
2020-04-01
Completion
2020-04-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04768530 on ClinicalTrials.gov