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Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy

NCT05657015 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2022-12-20

No results posted yet for this study

Summary

The objectives of this clinical study were to:

1. Assess the influence of Lepidium sativum in situ gel versus simvastatin gel on the clinical parameters in periodontitis patients as the primary objective.
2. Detect the effect of locally delivered Lepidium sativum and simvastatin gels on the nuclear factor kappa B (NF-κB) level in gingival crevicular fluid as the secondary objective.

Conditions

  • Periodontitis

Interventions

DRUG

Lepidium Sativum

2 ml of LS in situ gel at baseline

DRUG

Simvastatin

1.2% of SMV in situ gel at baseline

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • Hala Abuelela, Professor · Professor of Oral medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt

  • Olfat Shaker, Professor · Professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo university, Egypt

  • Dina Osman, Professor · Professor of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Girls), Al Azhar university, Egypt

  • Suzan Sarhan, PHD · Lecturer of Oral Medicine, Periodontology, and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-01
Primary Completion
2022-05-01
Completion
2022-07-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05657015 on ClinicalTrials.gov