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Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis

NCT04044417 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2019-08-07

No results posted yet for this study

Summary

Among the root conditioning materials is the Ethylenediaminetetraacetic acid (EDTA). EDTA exposes the collagen fibers on dentin surfaces and also enhances early cell colonization. Statins have an anti-inflammatory effect, inhibit the bone resorption and stimulate the bone formation. Curcumin is effective in preventing periodontal disease destruction by targeting both bacteria and host inflammatory cells. Curcumin has anti- inflammatory, antioxidant, anticarcinogenic, antiviral, and antimicrobial functions. This study will be carried out to examine the effect of simvastatin-curcumin paste following EDTA root surface etching when used in conjunction with open flap debridement treating deep periodontal pockets (suggesting that it may have positive effect)

Conditions

  • Periodontitis

Interventions

PROCEDURE

currettage

open flap debridement

DRUG

curcumin simvastatin paste

Curcumin is the primary active constituent of turmeric. Simvastatin is chemical modification of lovastatin.

DRUG

EDTA root conditioning

EDTA is an aminopolycarboxylic acid and a colourless, water-soluble solid

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • Ahmed Y Gamal, Professor · Faculty of dentistry- Ain shams university

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-08-25
Primary Completion
2018-05-05
Completion
2018-10-03

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04044417 on ClinicalTrials.gov