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Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis

NCT06153706 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2023-12-01

No results posted yet for this study

Summary

This study aimed to evaluate the efficacy of leukocyte platelet-rich fibrin (L-PRF) as a local sustained released device for antibiotics.

Conditions

  • Periodontitis

Interventions

DRUG

Subgingival application of L-PRF loaded with metronidazole

After phase I therapy, L-PRF loaded medical grade metronidazole was applied sub gingivally into the pockets using blunt gauge needle and Perio-pack was placed (two applications with one week apart were applied subgingivally.

OTHER

Subgingival application of L-PRF

The L-PRF alone was applied subgingivally into the pockets and Perio-pack was placed (two applications with one week apart.

Sponsors & Collaborators

  • Yasmeen Khaled

    lead OTHER

Principal Investigators

  • Yasmeen K Omar, BDS · Alexandria University

  • Mohy A El Rashidy, PhD · Alexandria University

  • Ghada Bassiouny, PhD · Alexandria University

  • Aliaa G Aboulela, PhD · University of Alexandria

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2023-10-01
Completion
2023-10-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06153706 on ClinicalTrials.gov