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IL-32 Isoforms Levels in GCF and Plasma of the Patients With Periodontitis

NCT04350489 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 54

Last updated 2020-04-20

No results posted yet for this study

Summary

Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. The aim of this study was to investigate the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in gingival crevicular fluid (GCF) and plasma before and after nonsurgical periodontal treatment in patients with periodontitis (P).Twenty-seven P and 27 periodontally healthy controls (C) were recruited in this study. Periodontitis patients were performed nonsurgical periodontal treatment. GCF and plasma sampling and clinical periodontal parameters were evaluated before and 1 month after treatment. Enzyme-linked immunosorbent assay was used to analyze the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in GCF and plasma samples.

Conditions

  • Periodontitis

Interventions

OTHER

Non-surgical periodontal treatment

Conventional non-surgical periodontal treatment were performed

Sponsors & Collaborators

  • Bulent Ecevit University

    lead OTHER

Eligibility

Min Age
25 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-10-01
Primary Completion
2019-05-01
Completion
2019-05-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04350489 on ClinicalTrials.gov