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Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingival Crevicular Fluid

NCT07243145 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2025-11-21

No results posted yet for this study

Summary

AIM: This prospective clinical study aimed to evaluate the efficacy of two distinct non-surgical periodontal therapy modalities in patients diagnosed with Stage 1 and Stage 2 periodontitis.

METHOD: The study comprised 80 nonsmoking, systemically healthy volunteers. Patients were divided into two groups at random: the Guided Biofilm Therapy (GBT) group and the convetional therapy group, which included Gracey curette and an ultrasonic device. All patients were assessed before and one and three months after therapy for clinical characteristics like pocket depth, Gingival Index (GI), Plaque Index (PI), Bleeding on Probing Index (BOP), and the levels of IL-1β, IL-10, TNF-α, and MMP-8 in gingival crevicular fluid (GCF).

RESULTS: ... CONCLUSION:...

Conditions

  • Peridontal Disease
  • Periodontal Inflammation
  • Periodontitis, Adult

Sponsors & Collaborators

  • Nigde Omer Halisdemir University

    collaborator OTHER

  • Niğde Ömer Halisdemir University

    collaborator UNKNOWN

  • Selcen Ozcan Bulut

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-15
Primary Completion
2025-04-15
Completion
2025-05-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07243145 on ClinicalTrials.gov