DirEct Versus VIdeo LaryngosCopE Trial

Summary

Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States. Failure to intubate the trachea on the first attempt occurs in more than 10% of all tracheal intubation procedures performed in the emergency department (ED) and intensive care unit (ICU). Improving clinicians rate of intubation on the first attempt could reduce the risk of serious procedural complications.

In current clinical practice, two classes of laryngoscopes are commonly used to help clinicians view the larynx while intubating the trachea: a video laryngoscope (equipped with a camera and a video screen) and a direct laryngoscope (not equipped with a camera or video screen). For nearly all laryngoscopy and intubation procedures performed in current clinical practice, clinicians use either a video or a direct laryngoscope. Prior research has shown that use of a video laryngoscope improves the operator's view of the larynx compared to a direct laryngoscope. Whether use of a video laryngoscope increases the likelihood of successful intubation on the first attempt remains uncertain. A better understanding of the comparative effectiveness of these two common, standard-of-care approaches to laryngoscopy and intubation could improve the care clinicians deliver and patient outcomes.

Conditions

• Acute Respiratory Failure

Interventions

OTHER

Video Laryngoscope

Laryngoscope with a camera and a video screen

OTHER

Direct Laryngoscope

Laryngoscope without a camera or a video screen

Sponsors & Collaborators

• University of Colorado, Denver

  collaborator OTHER

• Vanderbilt University Medical Center

  lead OTHER

Principal Investigators

• Matthew W Semler, MD, MSc · Vanderbilt University Medical Center

• Adit A Ginde, MD, MPH · University of Colorado, Denver

• Matthew E Prekker, MD, MPH · Hennepin County Medical Center, Minneapolis

• Stacy A Trent, MD, MPH · Denver Health Medical Center

• Brian E Driver, MD · Hennepin County Medical Center, Minneapolis

• Jonathan D Casey, MD, MSc · Vanderbilt University Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-03-19

Primary Completion

2022-11-17

Completion

2022-12-16

Countries

• United States

Study Locations