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Insulin and Muscle Fat Metabolism

NCT04759872 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2022-06-10

No results posted yet for this study

Summary

Our objective in this study is to identify the extent to which insulin drives the accumulation of lipids in skeletal muscle of humans. We will test the hypothesis that 4-hours of mild hyperinsulinemia will result in significant muscle lipid accumulation and that such effects will be similar in lean and overweight/obese humans.

Conditions

  • Overweight and Obesity
  • Insulin Resistance
  • Metabolic Disease
  • Mitochondrial Metabolism
  • Sedentary Lifestyle

Interventions

OTHER

Hyperinsulinemic-euglycemic Clamp

Participants will be administered a constant-rate insulin infusion (to induce mild hyperinsulinemia), with an infusion of dextrose to maintain blood glucose concentration (to maintain euglycemia).

Sponsors & Collaborators

  • Oregon State University

    lead OTHER

Principal Investigators

  • Sean A Newsom, Ph.D. · Oregon State University

  • Matthew M Robinson, Ph.D. · Oregon State University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
30 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-02-22
Primary Completion
2022-06-07
Completion
2022-06-07

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04759872 on ClinicalTrials.gov