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Role of Metformin on Muscle Health of Older Adults

NCT03107884 · Status: ACTIVE_NOT_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2025-12-05

No results posted yet for this study

Summary

Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health in bed ridden older adults has not been investigated.

Conditions

Interventions

DRUG

Metformin (Bed Rest)

A clinical oral dose of Metformin will be given to participant daily during bed rest

DRUG

Placebo (Bed Rest)

Placebo-comparator. The same quantity of non-active tablets will be given at the same time of day as the Metformin treatment group

DRUG

Metformin (2 week run-in only)

A clinical oral dose of Metformin will be given to participant daily during a two week run-in period only.

DRUG

Placebo (2 week run-in only)

Placebo-comparator. The same quantity of non-active tablets will be given at the same time of day as the Metformin 2 week run-in treatment group.

Sponsors & Collaborators

Principal Investigators

  • Micah Drummond · University of Utah

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-08-01
Primary Completion
2026-11-01
Completion
2026-11-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03107884 on ClinicalTrials.gov