MedTrace Logo

Metabolites Profiling Reveals Nutrient Processing Patterns Upon Dietary Loading

NCT05784506 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 147

Last updated 2025-09-18

No results posted yet for this study

Summary

The reasonable combination of macronutrients including carbohydrates, proteins and fat, is the basis of rational diet and beneficial to treatment of metabolic diseases including obesity and diabetes. Endocrine hormones play pivotal roles in regulation of nutrients metabolism and energy homeostasis. However, the dynamic metabolism following the consumption of macronutrients and the relationship between various metabolites and endocrine hormones during these procedures yet to be adequately explained nowadays. Therefore, in this study, the investigators selected glucose, protein, fat and mixed meal tolerance test (MMTT) for the loading tests, endocrine hormones and metabolites were detected to profile the molecular changes in the plasma. The investigators aimed to explore the nutrient processing patterns of various macronutrients and determine the interaction between metabolic hormones and metabolites.

Conditions

  • Metabolism Disorder
  • Nutrition

Interventions

OTHER

Macronutrients

Four successive food tolerance tests (glucose, protein, butter and olive oil) at one-week intervals.

OTHER

Mixed meal tolerance test (MMTT)

Mixed meal tolerance test (MMTT)

Sponsors & Collaborators

  • Nanjing Medical University

    lead OTHER

Principal Investigators

  • Tao Yang, MD/PhD · First Affiliated Hospital, Nanjing Medical University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2023-11-30
Completion
2023-12-31

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05784506 on ClinicalTrials.gov