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Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females

NCT04744142 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2021-02-08

No results posted yet for this study

Summary

Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat skeletal muscle wasting. Therefore, our aim is to investigate the effect of 3HHB intake on muscle wasting and its adverse consequences during a period of caloric restriction in lean females. In addition, we compare the effects of 3HHB intake with a high protein diet, which is currently considered as the best strategy to minimize lean loss during hypo-energetic periods. To end, we aim to investigate the synergistic effects of the intake of 3HHB in combination with a high protein diet.

Conditions

  • Muscle Wasting
  • Protein Intake
  • Ketosis
  • Caloric Restriction

Interventions

DRUG

Ketone supplementation

Subjects receive either placebo or ketone ester supplementation

DIETARY_SUPPLEMENT

Increased protein intake

Subjects receive either normal or increased protein intake

Sponsors & Collaborators

  • KU Leuven

    lead OTHER

Principal Investigators

  • Katrien Koppo, PhD · KU Leuven

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2018-12-20
Completion
2019-06-01

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04744142 on ClinicalTrials.gov