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Exogenous Ketosis During Bed Rest in Older Adults

NCT05679596 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2024-02-07

No results posted yet for this study

Summary

The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest. The main questions it aims to answer are:

Does supplementation of ketone bodies prevent the typical decline in muscle protein synthesis, muscle size, muscle function, insulin sensitivity, and muscle mitochondrial function that occurs in response to bed rest?

Researchers will compare ketone supplements (KET) to an energy matched control beverage (carbohydrates and fats) to see if the ketones can rescue the decline in muscle protein synthesis rates, muscle loss, muscle function, insulin sensitivity, and mitochondrial function due to 5 days of bed rest.

This may positively impact the heath of older adults subjected to bed rest.

Conditions

  • Muscle Protein Synthesis
  • Muscle Atrophy
  • Insulin Sensitivity
  • Mitochondrial Function
  • Physical Inactivity
  • Cognitive Function
  • Muscle Strength
  • Functional Capacity

Interventions

DIETARY_SUPPLEMENT

ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate

Provided twice a day between meals.

DIETARY_SUPPLEMENT

carbohydrate-fat placebo (fructose, corn and canola oil 50:50 ratio)

Provided twice a day between meals.

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • McGill University

    lead OTHER

Principal Investigators

  • Tyler A Churchward-Venne, PhD · McGill University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-27
Primary Completion
2023-11-15
Completion
2023-11-15

Countries

  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05679596 on ClinicalTrials.gov