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Neuroplasticity Induced by General Anaesthesia

NCT04125121 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2021-08-20

No results posted yet for this study

Summary

The aim of this study is to use magnetic resonance imaging to explore and compare possible de novo neuroplastic changes induced by the isolated effects of the hypnotic agents sevoflurane and propofol, respectively. In addition, to explore possible associations between neuroplastic changes and clinical and/or biochemical outcomes. It is a randomised, cross-over, single blinded clinical study. N = 30. Female:male ratio 1:1.

Conditions

  • Healthy Volunteers
  • General Anaesthesia
  • Neuroplasticity

Interventions

DRUG

Sevoflurane-propofol

General anaesthesia with a maintenance phase of two hours duration with either sevoflurane or propofol.

Sponsors & Collaborators

  • Signe Sloth Madsen

    lead OTHER

Principal Investigators

  • Signe Madsen, MD · Rigshospitalet, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-26
Primary Completion
2021-08-13
Completion
2021-08-13

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04125121 on ClinicalTrials.gov