A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane

Summary

Intravenous and inhalation combined anesthesia is a commonly used method for maintaining general anesthesia in clinical practice. This study aims to explore the interaction between ciprofol and sevoflurane. By employing response surface methodology, we constructed a three-dimensional pharmacodynamic interaction surface for various dose combinations of ciprofol and sevoflurane. This approach allows us to determine the nature of the interaction between the two drugs at any given level, thereby providing a ciprofol understanding of the dose-response relationship when ciprofol and sevoflurane are used in combination. This knowledge will serve as a theoretical basis for rational drug administration during surgery.

Conditions

• Induction of General Anesthesia

Interventions

DRUG

Sevoflurane 0 + different doses of ciprofol

Sevoflurane 0% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.6mg/kg, respectively.

DRUG

Sevoflurane 0.7% + different doses of ciprofol

Sevoflurane 0.7% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.5mg/kg, respectively.

DRUG

Sevoflurane 1.0% + different doses of ciprofol 0.05

Sevoflurane 1.0% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.

DRUG

Sevoflurane 1.5% + differnet doses of ciprofol

Sevoflurane 1.5% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.

DRUG

Sevoflurane 2.0% + different doses of ciprofol

Sevoflurane 2.0% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.

DRUG

Sevoflurane 2.5% + different doses of ciprofol

Sevoflurane 2.5% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.

DRUG

Ciprofol 0 + different end-expiratory concentration of sevoflurane

Ciprofol 0 combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5%, respectively.

DRUG

Ciprofol 0.05mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.05 mg/kg combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5 %, respectively.

DRUG

Ciprofol 0.1mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.1mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.

DRUG

Ciprofol 0.2 mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.2 mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.

DRUG

Ciprofol 0.3 mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.3 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.

DRUG

Ciprofol 0.4 mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.4 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.

Sponsors & Collaborators

• Sichuan Provincial People's Hospital

  collaborator OTHER

• Feng Gao

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-02-01

Primary Completion

2025-12-31

Completion

2025-12-31