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Anesthetic Neurotoxicity: the Association Between General Anesthesia and the Level of Plasma Neurofilament Light

NCT04164329 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2019-11-18

No results posted yet for this study

Summary

A prospective controlled single centre study designed to determine the association between the exposure to anesthetic agents and the pre and postoperative changes in plasma Neurofilament Light levels, biomarkers of neurological injury, in patients with similar surgical intervention but different anesthetic techniques.

Secondary endpoints: Association between the changes in plasma Neurofilament Light levels and the development of post-operative neurocognitive disorders as acute delirium.

Conditions

  • General Anesthetics Toxicity

Interventions

DRUG

General anesthetic

General anesthesia (propofol, fentanyl, sevorane, remifentanyl, rocuronium)

Sponsors & Collaborators

  • Cardiocentro Ticino

    lead OTHER

Principal Investigators

  • Tiziano TC Cassina, Professor · Cardiocentro Ticino

  • Stefania SB Buson, Dr.ssa · Cardiocentro Ticino

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-11
Primary Completion
2020-10-31
Completion
2020-10-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04164329 on ClinicalTrials.gov