Comparison of Two Anaesthetics on Brain During Brain Tumour Surgery

Summary

Anaesthesia and surgical stress during craniotomy can lead to brain damage and activation of inflammatory response. Consequently inflammatory cytokines (IL6, IL8, IL10) are released. Cell mediated immune balance can increase postoperative complications (infections, wound healing, multiple organ dysfunction). Many studies have shown that volatile anaesthetics reduce systemic and local inflammatory response during major surgery, but animal studies have shown that volatile anaesthetics can induce neuroinflammation (IL6, NF-κB) that leads to decline of cognitive function in rodent and possible human.

Our aim was to investigate how anaesthetic technique for craniotomy influences the release of inflammatory cytokines. Our hypothesis was that when optimal neuroprotective strategies are followed during surgery intravenous anaesthesia attenuates inflammatory response comparing to inhalational anaesthesia.

The investigators included 40 patients anaesthetised with remifentanil based anaesthesia with sevoflurane (S group) or propofol (P group).

Plasma levels of IL6, IL8, IL10 were measured during preoperative, perioperative and postoperative periods of both groups of patients. The investigators also noted emergence parameters, postoperative (pain, shivering, vomiting) and neurological complications after surgery.

Conditions

• Inflammation

Interventions

DRUG

Propofol

4-6 mg/kg/h during anaesthesia

DRUG

Sevoflurane

0.8 MAC

Sponsors & Collaborators

• University Medical Centre Ljubljana

  lead OTHER

Principal Investigators

• Jasmina Markovic Bozic, MD, MSC · CD of Anaesthesiology and Intensive Therapy, University Medical Centre Ljubljan

• Blaz Karpe, PHD · Faculty of Natural Science and Engineering, University of Ljubljana

• Iztok Potocnik, MD, MSC · CD of Anaesthesiology and Intensive Therapy, University Medical Centre Ljubljan

• Ales Jerin, PHD · CLINICAL INSTITUTE OF CLINICAL CHEMISTRY AND BIOCHEMISTRY, University Medical Centre Ljubljana

• Andrej Vranič, MD, PHD · CD of Neurosurgery, University Medical Centre Ljubljana

• Vesna Novak Jankovic, PROF, PHD · CD of Anaesthesiology and Intensive Therapy, University Medical Centre Ljubljana

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-05-31

Primary Completion

2013-12-31

Completion

2013-12-31

Countries

• Slovenia

Study Locations