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Sevoflurane General Anesthetic and Spatial Memory in Humans

NCT05991817 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 22

Last updated 2025-11-20

No results posted yet for this study

Summary

The goal of this observational study is to learn about the effect of general anesthetic on spatial memory in adults who will undergo to an elective surgery. The main question it aims to answer is:

• A surgical event under general anesthesia with sevoflurane transiently impairs spatial memory in humans and induces an increase in inflammatory cytokines.

Participants will perform a virtual maze test and plasma samples will be taken before and after surgery.

Conditions

  • Spatial Memory Disorder

Interventions

PROCEDURE

Surgery/general anesthesia

Adult patients between the ages of 30 and 50 who are to undergo elective surgery under general anesthesia will have their spatial memory tested and interleukin 1beta and alpha tumor necrosis measured before and after surgery.

Sponsors & Collaborators

  • University of Chile

    lead OTHER

Principal Investigators

  • Khaleed Etchegaray · University of Chile

  • Jamileth More, PhD · University of Chile

  • Antonello Penna, MD, PhD · University of Chile

Eligibility

Min Age
30 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-14
Primary Completion
2025-11-30
Completion
2025-12-30

Countries

  • Chile

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05991817 on ClinicalTrials.gov