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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

NCT05991453 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 13000

Last updated 2025-08-05

No results posted yet for this study

Summary

The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries

Conditions

  • Surgery-Complications
  • Anesthesia Complication
  • Anesthesia Awareness
  • Anesthesia
  • Surgery
  • Quality of Life
  • Pain, Postoperative
  • Anesthesia Morbidity

Interventions

OTHER

Anesthetic technique Propofol TIVA

Propofol TIVA no inhaled agent

OTHER

Anesthetic technique inhaled agent

Must administer inhaled agent.

Sponsors & Collaborators

  • Patient-Centered Outcomes Research Institute

    collaborator OTHER

  • University of Michigan

    collaborator OTHER

  • Washington University School of Medicine

    lead OTHER

Principal Investigators

  • Sachin Kheterpal, MD · University of Michigan

  • Michael S Avidan, MBBCh · Washington University School of Medicine

  • Allison Janda, MD · University of Michigan

  • Mark Neuman, MD · University of Pennsylvania

  • Bethany Pennington, PharmD · Washington University School of Medicine

  • Douglas Colquhoun, MBChB · University of Michigan

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-13
Primary Completion
2027-07-31
Completion
2028-07-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05991453 on ClinicalTrials.gov