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Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.

NCT03772054 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2019-12-12

No results posted yet for this study

Summary

Endothelial damage has been reported after ischemia-reperfusion events. This can be characterized by measurements of glycocalyx and endothelial components that are released to blood after the insult. Sevoflurane and inhaled anesthetic commonly used for surgery have shown protective endothelial effects in animal and in-vitro models. Knee-ligament surgery with the use of a femoral tourniquet generates a transient ischemia-reperfusion (IR) state after the tourniquet is released. This research aims to compare the effect of sevoflurane and propofol in the release of glycocalyx and endothelial biomarkers after IR in this surgical scenario.

Conditions

  • Ischemia Reperfusion Injury

Interventions

DRUG

Sevoflurane

Inhalation anesthetic agent

DRUG

Propofol

Intravenous anesthetic agent

Sponsors & Collaborators

  • University of Chile

    lead OTHER

Principal Investigators

  • Felipe Maldonado, M.D., M.Sc. · Hospital Clìnico de la Universidad de Chile.

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-20
Primary Completion
2019-12-11
Completion
2019-12-11

Countries

  • Chile

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03772054 on ClinicalTrials.gov