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Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection

NCT03422315 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2021-06-09

No results posted yet for this study

Summary

Propofol is a widely used sedative anesthetic, but there are large individual differences, which making different patients with different sensitivity to propofol. The aim of this study was to analyze the effects of age, height, body weight, Drinking, metabolic enzymes CYP2B6 and UGT1A9 on Pharmacological effects and pharmacokinetics of propofol, and to provide a reasonable reference for clinical anesthesia patients and evidence for individual dosage regimens.

Conditions

  • General Anesthesia

Interventions

DRUG

Propofol

injection;2mg/kg;single-dose

Sponsors & Collaborators

  • Zhongyuan Xu

    lead OTHER

Principal Investigators

  • zhongyuan xu, Ph.D. · Nanfang Hospital, Southern Medical University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-03
Primary Completion
2021-09-30
Completion
2021-09-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03422315 on ClinicalTrials.gov