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Analysis of Autonomic Function During Anesthesia Using Response Surface Model

NCT03072069 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2019-02-28

No results posted yet for this study

Summary

Anesthesia in the modern age is at least a two-drug process consisting of an opioid and a sedative hypnotic (e.g., fentanyl and propofol in combination, among others). Therefore, it is important to understand the interaction pharmacodynamics of these agents as they are used clinically. A good method for visualizing the pharmacodynamic interaction behavior of drug combinations is through response surface models. Unlike traditional isobolograms that represent the concentrations of two agents that combine to produce a single degree of drug effect, response surface models characterize the complete spectrum of interaction between two or more agents for all possible levels of concentration and effect. The investigators try to use the response surface model to evaluate the effect of anesthetic combination of autonomic system.

Conditions

  • Anesthesia; Reaction
  • Autonomic Imbalance

Sponsors & Collaborators

  • National Central University

    lead OTHER

Principal Investigators

  • Chien-Kun Ting, PhD · National Yang Ming Chiao Tung University

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-21
Primary Completion
2018-02-21
Completion
2018-02-21

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03072069 on ClinicalTrials.gov