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Neuronal Inertia in Propofol Anesthesia

NCT01962285 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2013-10-14

No results posted yet for this study

Summary

Loss and recovery of consciousness during propofol anesthesia seem to be mediated by different mechanisms beyond the actual effect-site concentration of anesthetic drug. This eventual difference between dose response curves for loss of consciousness (LOC) and for recovery of consciousness (ROC) beyond hysteresis has received the name of neuronal inertia. We performed a volunteer-study comparing LOC and ROC curves during a slow, steady-sate, stepped target controlled infusion of Propofol. Our hypothesis is that, at steady-state conditions between plasma an effect-site concentration, there is still going to exist a difference between LOC and ROC, demonstrating the existence of neuronal inertia.

Conditions

  • General Anesthesia
  • Propofol Pharmacodynamics
  • Propofol Target Controlled Infusion
  • Loss of Consciousness and Recovery of Consciousness
  • Propofol Plasma Concentration

Interventions

DRUG

propofol targel controlled infusion

slow stepped propofol target controlled infusion using Schinider´s pharmacokinetic parameters seriated venous blood sampling

Sponsors & Collaborators

  • Universidad del Desarrollo

    lead OTHER

Principal Investigators

  • pablo sepulveda, anesthesiologist · Universidad del Desarrollo

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-08-31
Primary Completion
2013-09-30
Completion
2013-10-31

Countries

  • Chile

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01962285 on ClinicalTrials.gov