MedTrace Logo

The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal

NCT03806829 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 7

Last updated 2019-01-16

No results posted yet for this study

Summary

High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.

Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.

Conditions

  • Endothelial Dysfunction

Interventions

OTHER

Water

250 ml

OTHER

Red Wine

250 ml

OTHER

Green Tea

250 ml

OTHER

Orange Juice

250 ml

Sponsors & Collaborators

  • University of the Highlands and Islands

    lead OTHER

Principal Investigators

  • Ian Megson, Megson · University of the Highlands and Islands

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-06-06
Primary Completion
2018-07-31
Completion
2018-07-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03806829 on ClinicalTrials.gov