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Ventilator Hyperinflation and Hemodynamics

NCT03557645 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17

Last updated 2020-08-14

No results posted yet for this study

Summary

Ventilator hyperinflation (VHI) has been shown to be effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated patients; however, the literature is scarce concerning its safety and adverse effects. Thus, the aim of this study is to compare the hemodynamic repercussions of VHI in volume-controlled mode. In a randomized, controlled and crossover design, 24 mechanically ventilated patients will undergo 2 modes of ventilator hyperinflation (with and without an inspiratory pause) and a control intervention. Cardiac output, cardiac index, mean arterial pressure, pulmonary vascular resistance, systolic volume and other hemodynamic variables will be recorded during the interventions.

Conditions

Interventions

DEVICE

Baseline Mechanical Ventilation

The subjects will be kept in Volume Control Continuous Mandatory Ventilation (VC-CMV).

DEVICE

VHI With Inspiratory Pause

Application of a ventilator hyperinflation intervention with Volume Control Continuous Mandatory Ventilation (VC-CMV) with an inspiratory pause.

DEVICE

VHI Without Inspiratory Pause

Application of a ventilator hyperinflation intervention with Volume Control Continuous Mandatory Ventilation (VC-CMV) without an inspiratory pause.

Sponsors & Collaborators

  • Universidade Federal do Rio de Janeiro

    collaborator OTHER

  • Centro Universitário Augusto Motta

    lead OTHER

Principal Investigators

  • Fernando Guimaraes, PhD · Centro Universitário Augusto Motta

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-05
Primary Completion
2018-09-20
Completion
2018-09-30

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03557645 on ClinicalTrials.gov