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Oxygen Supplementation and Ventilator Hyperinflation in the Endotracheal Suction (OSVHES)

NCT02440919 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2022-08-15

No results posted yet for this study

Summary

This is a double crossover study where all patients are randomly allocated to one of two treatment sequences associated with endotracheal aspiration.The first treatment (A) uses two suctioning methods for each patient: one involving hyperoxygenation with administration of 100% oxygen 1 minute before and after suction (intervention I), and the other hyperoxygenation with oxygen supply to 20% above basal offer (Intervention II) in the same way.The second treatment (B) uses a technique of hyperinflation with the mechanical ventilator (PEEP-ZEEP) associated with hyperoxygenation. The intervention I, uses PEEP-ZEEP offering 20% above basal oxygenation and intervention II uses the PEEP-ZEEP with basal oxygen supply in the same way.

All subjects were randomly allocated using sealed envelopes to a treatment sequence A or B on Day 1. Patients received two treatments, at least four hours apart. The first treatment is in the morning and the alternate treatment is performed in the afternoon. On Day 2 the order of the treatments was reversed using the same patient position sequence.The interventions I and II are performed at least 4 hours apart to minimize any carryover effect.

Conditions

  • Hypoventilation
  • Hypoxemia

Interventions

OTHER

Hyperoxygenation 100% FiO2

Endotracheal suction associated with Hyperoxygenation involved supplying 100% oxygen.

OTHER

Hyperoxygenation 20% FiO2

Endotracheal suction associated with Hyperoxygenation involved supplying 20% oxygen above FiO2 basal.

OTHER

Hyperinflation (PEEP- ZEEP) Basal FiO2

Endotracheal suction associated ventilator hyperinflation (PEEP-ZEEP maneuver) and involved no hyperoxygenation, keeping the oxygen already offered to the patient.

OTHER

Hyperinflation (PEEP- ZEEP) 20% FiO2

Endotracheal suction associated ventilator hyperinflation (PEEP-ZEEP maneuver) and hyperoxygenation involved supplying 20% oxygen.

Sponsors & Collaborators

  • Universidade Federal de Sao Carlos

    lead OTHER

Principal Investigators

  • Jacqueline RF Vianna, Master · UFSCar

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2015-01-31
Completion
2030-12-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02440919 on ClinicalTrials.gov