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Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory Failure

NCT06042036 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 422

Last updated 2023-11-18

No results posted yet for this study

Summary

The goal of this observational study is to estimate the prevalence of the use of protective ventilation with low tidal volume ventilation in the transition of spontaneous ventilation modes in patients with hypoxemic acute respiratory failure in ICUs in Latin America and its association with patient outcomes.

The main questions it aims to answer are:

* what is the prevalence of the use of low tidal volume ventilation (VT \<8 mL/kg of predicted body weight) in the first 24 hours of spontaneous ventilation modes in patients with hypoxemic acute respiratory failure?
* Is there an association between the rate of adherence to low tidal volume ventilation in spontaneous ventilation modes and the ability to stay off ventilatory support and mortality?

Participants are patients with acute respiratory failure under mechanical ventilation. Investigators will collect data on the ventilatory parameters of participants

* 24 hours before they begin to be ventilated with spontaneous modes of ventilation
* during the first 24 hours of spontaneous ventilation

Investigators will collect several patient-centered clinical outcomes at 28 days after study inclusion, including ventilator-free days and mortality

Conditions

  • Respiration, Artificial
  • Acute Hypoxemic Respiratory Failure
  • Respiratory Insufficiency

Interventions

OTHER

Spontaneous mode of mechanical ventilation

any mode of mechanical ventilation classified as spontaneous or proportional, mainly pressure support ventilation, but also CPAP, APRV, NAVA, PAV+

Sponsors & Collaborators

  • Brazilian Research In Intensive Care Network

    collaborator NETWORK

  • Latin American Intensive Care Network (LIVEN)

    collaborator UNKNOWN

  • University of Sao Paulo General Hospital

    lead OTHER

Principal Investigators

  • JULIANA C FERREIRA, MD · University of Sao Paulo

Eligibility

Min Age
18 Years
Max Age
110 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-12
Primary Completion
2024-06-12
Completion
2024-10-12

Countries

  • Argentina
  • Bolivia
  • Brazil
  • Chile
  • Colombia
  • Ecuador
  • Mexico
  • Paraguay
  • Peru
  • Uruguay

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06042036 on ClinicalTrials.gov