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Impact of Aluminum on Sperm DNA Quality

NCT03549533 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2022-03-11

No results posted yet for this study

Summary

Between 1950 and 2013, aluminum production was multiplied by thirty in the world. Today, men's exposure to aluminum, including food products, cosmetics, air and water contamination, and a number of drugs (vaccine, gastric bandages, etc.) has never been so high and should continue to increase. At the same time, we are witnessing a decline in male fertility in Western countries.

In this context, several teams, including ours, have studied the impact of aluminum on the fertility of men. These studies have shown that aluminum accumulates in semen and especially in sperm near its DNA.

Aluminum has already shown that it is capable of damaging the DNA of various cells, especially to increase DNA fragmentation. We therefore hypothesize that aluminum could lead to increased sperm DNA fragmentation. This would result in a decrease of men fertility and in higher risk of miscarriage.

Conditions

  • Insemination, Artificial

Interventions

OTHER

samples of sperm

As in the usual practice during artificial insemination a samples of sperm will be collected and analyzed.

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Saint Etienne

    lead OTHER

Principal Investigators

  • Jean-Philippe KLEIN, MD · CHU SAINT-ETIENNE

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-06-13
Primary Completion
2021-09-07
Completion
2021-09-22

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03549533 on ClinicalTrials.gov