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sperDNA Fragmentation a a Predictor for Outcome After Varicocelectomy,m

NCT07144891 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 1

Last updated 2025-08-28

No results posted yet for this study

Summary

Varicocele is often associated with infertility and reduction in sperm quality, and it is one of the most common causes of reversible male infertility.

The exact mechanism of infertility caused due to varicocele formation remains unclear. One of the suggested theories is related to increased oxidative stress that causes sperm DNA damage, including DNA fragmentation, and is correlated with the decreased capacity of spermatozoa to fertilize oocytes during normal fertilization and assisted reproduction techniques. This is supported by the evidence that there is a higher prevalence of DNA fragmentation in varicocele patients and a correlation between the presence of varicocele and impaired sperm DNA integrity.

Several tests have been developed to better assess the fertility potential of sperm, including those designed to measure sperm deoxyribonucleic acid (DNA) fragmentation (SDF). The sperm DNA fragmentation index (DFI) is a potential parameter for fertility investigation, reflecting sperm DNA integrity and damage.

Conditions

  • DNA Damage

Interventions

GENETIC

Sperm DNA fragmentation

Estimation of sperm DFI level with sperm chromatin dispersion

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2026-10-01
Completion
2026-10-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07144891 on ClinicalTrials.gov