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Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System

NCT02364934 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 240

Last updated 2015-02-26

No results posted yet for this study

Summary

To explore and compare the effects of propoful, sevoflurane, and a combination of both on the pharmacokinetics and pharmacodynamics of rocuronium.

To discover and confirm sex differences on the pharmacokinetics and pharmacodynamics of rocuronium.

To evaluate and examine aged people on the pharmacokinetics and pharmacodynamics of rocuronium.

Conditions

  • TOF
  • Sex

Interventions

DRUG

Propofol

This study was designed to determine the dose requirements for rocuronium, administered by continuous infusion to maintain a stable 90-99% T1 depression (depression of the first twitch in the train-of-four, TOF) in adult, elderly and different sex patients under sufentanil and propoful anaesthesia.

DRUG

Sevoflurane

This study was designed to determine the dose requirements for rocuronium, administered by continuous infusion to maintain a stable 90-99% T1 depression (depression of the first twitch in the train-of-four, TOF) in adult, elderly and different sex patients under sufentanil and sevoflurane anaesthesia.

Sponsors & Collaborators

  • Tianjin Medical University General Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2017-01-31
Completion
2018-01-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02364934 on ClinicalTrials.gov