MedTrace Logo

Impact of Propofol Reduction in Anesthesia Induction

NCT04194151 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 192

Last updated 2020-08-12

Study results available
· View outcomes & findings →

Summary

Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved.

Methods: Patients were randomized into time groups (2 and 1 minute) and each subdivided into dose groups (1, 1.5 and 2 mg kg-1) obtaining six time-dose groups. After receiving 2 μg kg-1 of fentanyl, propofol was administered after the predetermined time. Time to hypnosis (BIS\<60) and hemodynamic parameters at pre-induction, pre-intubation and postintubation were registered.

Conditions

  • Propofol Adverse Reaction
  • Anesthesia

Interventions

DRUG

Propofol Injection

1, 1.5 or 2 mg/kg of propofol according to the subgroup

Sponsors & Collaborators

  • Hospital Central de la Defensa Gómez Ulla

    lead OTHER

Principal Investigators

  • Paula A Vullo, MD

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-11-01
Primary Completion
2018-10-26
Completion
2018-10-26

Countries

  • Spain

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04194151 on ClinicalTrials.gov