Acute Effects of Blackcurrant and Citrus Polyphenol Extracts on Postprandial Glycaemia

Summary

Large postprandial glucose responses are associated with increased risk of chronic diseases, including diabetes and cardiovascular disease. Our group have previously shown that fruit polyphenol extracts, when consumed immediately before a mixed carbohydrate meal, reduce postprandial glycaemia. The aim of this study is to investigate the effects of a blackcurrant polyphenol extract and citrus polyphenol extract (and their combination), on postprandial glycaemia, insulinaemia and gastrointestinal hormone concentrations following a mixed carbohydrate test meal. It is hypothesised that blackcurrant and citrus extracts alone will inhibit glycaemia compared to placebo, and a combination of the two will have a greater effect.

Conditions

• Postprandial Period

Interventions

DIETARY_SUPPLEMENT

Blackcurrant extract (low dose)

Participants will consume a small beverage that contains blackcurrant extract (low dose) immediately before a high-carbohydrate meal.

DIETARY_SUPPLEMENT

Placebo

Participants will consume a small beverage that contains no fruit extracts immediately before a high-carbohydrate meal.

DIETARY_SUPPLEMENT

Citrus extract (low dose)

Participants will consume a small beverage that contains citrus extract (low dose) immediately before a high-carbohydrate meal.

DIETARY_SUPPLEMENT

Blackcurrant extract (high dose)

Participants will consume a small beverage that contains blackcurrant extract (high dose) immediately before a high-carbohydrate meal.

DIETARY_SUPPLEMENT

Blackcurrant and citrus extracts (low dose / low dose)

Participants will consume a small beverage that contains blackcurrant and citrus extracts (low dose / low dose)immediately before a high-carbohydrate meal.

Sponsors & Collaborators

• King's College London

  collaborator OTHER

• Lucozade Ribena Suntory

  lead INDUSTRY

Principal Investigators

• Wendy L Hall, PhD · King's College London

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-05-30

Primary Completion

2018-02-01

Completion

2018-06-01

Countries

• United Kingdom

Study Locations