Digestibility of Selected Resistant Starches in Humans

Summary

Dietary fiber is a type of carbohydrate which is not digested in the human small intestine. Whole grains are a source of dietary fiber that are used to promote health; however, using whole grains in commercial products results in a different taste and/or texture than the usual products made from refined grains. Thus, other types of high-fiber ingredients have been developed which can be incorporated into food products with less effect on their taste and/or texture. An example of this is resistant starch, defined as starch which is not digested in the human small intestine. The digestibility of starch is usually determined in-vitro; however, there is evidence that such methods may overestimate the amount of resistant starch by as much as 100%. The measurement of the amount of carbohydrate in the ileal effluent, digestive waste, of subjects with an ileostomy is considered to be the best in-vivo method of starch digestibility. The subjects collect ileal effluent during the day during which time they consume a polysaccharide-free diet. There is evidence that resistant starch consumed at breakfast is completely recovered in ileal effluent 8-10hr after consumption. The purpose of this study will be to compare the carbohydrate content recovered in ileal effluent of 10 subjects with a conventional ileostomy.

Conditions

• Malabsorption; Carbohydrate
• Ileostomy - Stoma

Interventions

OTHER

Starch-free breakfast

Starch-free breakfast alone

OTHER

Hi-Maize 260

Starch-free breakfast plus 55.3g Hi-Maize 260

OTHER

Hylon VII

Starch-free breakfast plus 56.9g Hylon VII

OTHER

Amioca

Starch-free breakfast plus 56.4g amioca starch

Sponsors & Collaborators

• Ingredion Incorporated

  collaborator INDUSTRY

• University of Toronto

  collaborator OTHER

• Glycemic Index Laboratories, Inc

  collaborator INDUSTRY

• Iowa State University

  collaborator OTHER

• Unity Health Toronto

  lead OTHER

Principal Investigators

• Thomas M. Wolever, MD, PhD · Unity Health Toronto

Study Design

Allocation

NA

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-09-30

Primary Completion

2013-12-31

Completion

2014-08-31

Countries

• Canada

Study Locations