Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery

Summary

The purpose of this study is to investigate the effects of treatment for specific language deficits in people with aphasia. In addition to language and cognitive measures, changes in brain function will also be gathered before and after the treatment is administered in order to track any changes resulting from receiving treatment.

Conditions

• Aphasia
• Dysgraphia
• Anomia
• Agrammatism
• Stroke

Interventions

BEHAVIORAL

Treatment Focusing on Naming Objects

Treatment will be administered from week 0 until week 12.

BEHAVIORAL

Treatment Focusing on Improving Spelling Abilities

Treatment will be administered from week 0 until week 12.

BEHAVIORAL

Treatment Focusing on Improving Sentence Processing

Treatment will be administered from week 0 until week 12.

BEHAVIORAL

No Treatment

No treatment will be administered.

Sponsors & Collaborators

• National Institute on Deafness and Other Communication Disorders (NIDCD)

  collaborator NIH

• National Institutes of Health (NIH)

  collaborator NIH

• Northwestern University

  lead OTHER

Principal Investigators

• Cynthia K Thompson, PhD · Northwestern University

• David Caplan, MDCM, PhD · Harvard University Massachusetts General Hospital

• Brenda Rapp, PhD · Johns Hopkins University

• Swathi Kiran, PhD, CCC-SLP · Boston University

• Todd B Parrish, PhD · Northwestern University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

35 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-04-30

Primary Completion

2019-03-27

Completion

2019-03-27

Countries

• United States

Study Locations