BioNTech presented phase 2 data for HER2-directed ADC Trastuzumab Pamirtecan showing 47.9% response rate in endometrial cancer, with FDA submission planned for 2026. BioLineRx dosed first patient in phase 1/2a GLIX1 trial for glioblastoma and reported new preclinical data. Both companies presented at ASCO 2026.
Northwestern University researchers found that levetiracetam, an FDA-approved anti-seizure medication, prevents formation of toxic amyloid-beta 42 peptides in the brain, offering a potential strategy for early Alzheimer's prevention.
Researchers have developed advanced platforms to study human neural networks, including 3D bioelectronics for brain organoids and scalable 2D neuron networks that reveal brain-like rhythms and drug responses.
Scientists at Northwestern University developed human spinal cord organoids that accurately replicate injury responses including cell death, inflammation, and glial scarring. Testing showed a "dancing molecules" therapy significantly reduced scarring and promoted nerve regrowth.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07612475 |
Type 1 Diabetes Screening |
NOT_YET_RECRUITING | |
| NCT07610655 |
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression |
RECRUITING | NA |
| NCT07607613 |
Parents and Babies Pilot |
NOT_YET_RECRUITING | NA |
| NCT07604272 |
Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males |
NOT_YET_RECRUITING | PHASE1 |
| NCT07594626 |
BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT07594548 |
Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma |
NOT_YET_RECRUITING | PHASE1 |
| NCT07586046 |
Defining the Ablative Dose for Y-90 TARE |
NOT_YET_RECRUITING | PHASE2 |
| NCT07580404 |
Emsella for Reducing tSUI After HOLEP |
NOT_YET_RECRUITING | NA |
| NCT07580391 |
Utilization of a Web-Based Application to Improve Patient Health Literacy and Reduce Clinic Visit Times in Holmium Laser Enucleation of the Prostate (HoLEP) Procedures and Kidney Stone Surgery |
ACTIVE_NOT_RECRUITING | NA |
| NCT07564388 |
Cochlear-Implant-Performance-Prediction |
ENROLLING_BY_INVITATION | NA |
