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Cognition, Flavonoids, Exercise, Gut Microbiome

NCT06495190 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2025-03-12

No results posted yet for this study

Summary

This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.

Conditions

  • Cognitive Decline, Mild

Interventions

DIETARY_SUPPLEMENT

Blueberry

50 g/d blueberry powder supplement

BEHAVIORAL

Walking

Five 45-min walking sessions per week

DIETARY_SUPPLEMENT

Placebo

50 g/d placebo powder supplement

BEHAVIORAL

Stretching

Five 45-min stretching sessions per week

Sponsors & Collaborators

  • Appalachian State University

    lead OTHER

Principal Investigators

  • David C Nieman, DrPH · Appalachian State Univ

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06495190 on ClinicalTrials.gov