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Characterizing Knee Pain and Response to Surgery Using Local Biomarkers

NCT00961623 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2019-06-04

No results posted yet for this study

Summary

The diagnosis and monitoring of clinically-significant pathologies of the knee remains challenging, and it is unknown why only some injuries become painful or respond to surgical intervention. The limitations of diagnostic magnetic resonance imaging result in arthroscopy that is not always beneficial. Elucidation of biochemical pathways underlying pain in this condition may aid patient selection for surgery and provide pharmacotherapeutic targets. Cytokines or a novel yet uncharacterized protein may be involved in pain following meniscus injury and diagnostic cytokine assay may help physicians differentiate patients that may benefit from arthroscopy from those that may not. Additionally, evaluating post-operative biochemical profiles may provide a method of monitoring surgical outcome and understanding post-operative continuation or remission of pain.

Conditions

Sponsors & Collaborators

Principal Investigators

  • Jason L Dragoo, MD · Stanford University

  • Eric Leroux · Stanford University

  • Amy Wasterlain · Stanford University

  • Gaetano Scuderi, MD · Stanford University

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2011-12-31
Completion
2011-12-31

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00961623 on ClinicalTrials.gov