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Large-scale ex Vivo Expansion and Characterization of Two Kinds of MSC From Knee for Clinical Application

NCT02386163 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2015-09-10

No results posted yet for this study

Summary

According to many researches, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.

Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of TKR (Total Knee Replacement). The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare their characterization and potential for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with "Good Tissue Practices (GTP)".

Conditions

  • Knee Injuries

Interventions

BIOLOGICAL

MSC from synovial membrane and infrapatellar Fat Pad

Sponsors & Collaborators

  • Far Eastern Memorial Hospital

    collaborator OTHER

  • EMO Biomedicine Corporation

    lead INDUSTRY

Principal Investigators

  • Chih-Hung Chang, MD, Ph.D · Far Eastern Memorial Hospital

  • Shing-Mou Lee · EMO Biomedicine Corp.

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2015-08-31
Completion
2015-08-31

Countries

  • Taiwan

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02386163 on ClinicalTrials.gov