Three FcRn inhibitors are approved for generalized myasthenia gravis, with a head-to-head trial of efgartigimod and nipocalimab underway. Emerging therapies including telitacicept, gefurulimab, and CAR-T cell therapy (KYV-101) show promise, while Immunovant's batoclimab failed TED trials.
Researchers at McMaster University said their SyntheMol-RL AI model designed a new antibiotic candidate called synthecin. In mouse wound infection models, the topical compound was highly effective against drug-resistant Staphylococcus aureus.
The FDA approved Bracco's Vueway for neonates and infants at half the standard gadolinium dose, accepted Bayer's gadoquatrane application for a 60% dose reduction, and granted Breakthrough Device designation to Radiology Partners' AI chest X-ray tool.
Researchers at Stanford and Harvard are developing nasal spray vaccines offering broad protection against respiratory infections, with early animal and phase 1 human trials showing safety and potential efficacy.
National Institutes of Health Director Jay Bhattacharya will serve as acting director of the Centers for Disease Control and Prevention following Jim O'Neill's departure. Bhattacharya will oversee both agencies simultaneously as the CDC faces significant instability.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07601295 |
Tiprelestat Versus Placebo When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH) |
NOT_YET_RECRUITING | PHASE2 |
| NCT07601061 |
Simplifying Diet Tracking in a Digital Weight Loss Intervention |
NOT_YET_RECRUITING | NA |
| NCT07600658 |
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT07594431 |
Trial Comparing LATTICE Radiotherapy vs Moderately Dose-escalated Palliative Radiation for Patients With Metastases. |
NOT_YET_RECRUITING | PHASE2 |
| NCT07580352 |
Assessing the Feasibility of Using Virtual Reality Experiences in Older Adults |
COMPLETED | NA |
| NCT07579299 |
Engaging Family Members During Early SUD Treatment: A Hybrid Trial |
NOT_YET_RECRUITING | NA |
| NCT07577999 |
The Effects of Cannabis on Post Operative Recovery After Radical Cystectomy |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07573982 |
Ultrasonic Debris Clearance to Promote Brain Resilience |
NOT_YET_RECRUITING | NA |
| NCT07572591 |
Ultrasound for Peripheral Nerve Modulation |
NOT_YET_RECRUITING | NA |
| NCT07572500 |
MEA DPA Hypoxic Event Reductions |
WITHDRAWN | NA |
