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the New Biomarker of the Knee Osteoarthritis Knee Osteoarthritis Occurrence and Progression

NCT03015688 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 460

Last updated 2017-01-10

No results posted yet for this study

Summary

It was previously proved an association of TGF-β1 and PDGF-BB with the pathogenesis of osteoarthritis (OA) by experiments of OA animal models. In this study, we aimed to determine whether serum concentrations of TGF-β1, PDGF-BB and CTX-1 were related to the knee OA. knee OA cases were collected from the first affiliated hospital of Shihezi university and healthy controls were recruited from the community. The severity of knee OA was defined as kellgren-lawrence (K-L) classification criteria.Serum levels of chemical biomarkers were compared between knee OA cases and controls or among K-L grade 2 to grade 4 groups. The serum concentrations of the TGF-β1, PDGF-BB and CTX-1 were determined by ELISA .

Conditions

Interventions

RADIATION

x-ray images

Sponsors & Collaborators

  • Shihezi University

    lead OTHER

Eligibility

Min Age
38 Years
Max Age
78 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-06-30
Primary Completion
2015-01-31
Completion
2015-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03015688 on ClinicalTrials.gov